一、个人基本情况
黄力行,男,1986年11月出生,副教授,硕士生导师。2014年7月毕业于厦门大学生命科学学院,获博士学位。
二、主要研究兴趣
1. 水产病原微生物致病分子机理研究。
2. 鱼、虾、海参等半开放养殖区重要疫病病原微生物的种类、丰度和分布特征调研,分析其遗传进化特点和演变规律,建立重要病原微生物快速检测技术和重要病原微生物名录。
三、科研项目
主持“新型非编码RNA Vvrr1参与溶藻弧菌毒力调控的机制研究”(国家自然科学基金青年科学基金项目)
主持“温度敏感Pyoverdine合成酶编码基因L321_07973调控变形假单胞菌致病性的分子机制初步研究”(福建省自然科学基金计划项目)
主持“铁载体合成酶编码基因L321_00207对变形假单胞菌致病性的影响”(福建省中青年教师教育科研项目)
主持“大黄鱼内脏白点病口服疫苗研发”(大黄鱼企业国家重点实验室开放课题)
主持“Pyoverdine合成酶编码基因L321_01406调控变形假单胞菌致病性的初步研究”(李尚大学科建设基金)
主持“利用RNAi技术研究Flagellar assembly pathway在溶藻弧菌粘附过程中的作用”(农业部东海海水健康养殖重点实验室开放性课题)
主持“溶藻弧菌转录组测序所显示的三个新基因的功能初步鉴定”(国家海洋局海洋生物遗传资源重点实验室开放性课题)
参与“LuxR家族调控蛋白对嗜水气单胞菌在鳗鲡巨噬细胞内存活的调控及机制研究”(国家自然科学基金青年科学基金项目)
参与“全反式维甲酸调控miR-34a-E2F1/3-Eag1信号通路抑制骨肉瘤恶性表型的研究”(国家自然科学基金青年科学基金项目)
参与“海洋渔用疫苗工程技术研究中心”(海洋经济区域创新发展示范项目)
参与“海水鱼益生菌及海水净化微生物制剂开发与产业化”(厦门市海洋经济发展专项资金项目)
参与“几种高附加值海洋天然产物规模化生产关键技术研究与示范”(海洋公益性行业科研专项经费项目)
参与“用斑马鱼模型研究多环芳烃的心血管发育毒性及其机制”(国家自然科学基金)。
参与“利用斑马鱼研究多环芳烃的视觉发育毒性和机制”(国家自然科学基金)。
参与“海洋药源生物种质资源库建设课题子课题”(国家海洋局)
参与“‘重大项目为牵引,导师团队为保障’研究生创新能力培养研究”(福建省本科高校教育教学改革研究项目)
四、近年发表论文
1. Huang L X, Wang L, Lin X Z, Su Y Q, Qin Y X, Kong W D, Zhao L M, Xu X J, Yan Q P. mcp, aer, cheB, and cheV contribute to the regulation of Vibrio alginolyticus (ND-01) adhesion under gradients of environmental factors. MicrobiologyOpen, 2017, doi: 10.1002/mbo3.517. (IF: 2.747)
2. Liu W J, Huang L X, Su Y Q, Qin Y X, Zhao L M, Yan Q P. Contributions of the oligopeptide permeases in multistep of Vibrio alginolyticus pathogenesis. Microbiologyopen, 2017, doi: 10.1002/mbo3.511. (Co-first authors). (IF: 2.747)
3. Zhang Y Y, Huang L X, Zhao Y J, Hu T H. Musk xylene induces malignant transformation of human liver cell line L02 via repressing the TGF-β signaling pathway. Chemosphere, 2017, 168:1506-1514. (Co-first authors). (IF: 4.21)
4. Huang L X, Xi Z H, Wang C G, Zhang Y Y, Yang Z B, Zhang S Q, Chen Y X, Zuo Z H. Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation. Scientific Reports, 2016, 6. (IF: 5.23)
5. Luo G, Huang L X, Su Y Q, Qin Y X, Xu X J, Zhao L M, Yan Q P. flrA, flrB and flrC regulate adhesion by controlling the expression of critical virulence genes in Vibrio alginolyticus. Emerg Microbes Infect. 2016, 5(8): e85. (Co-first authors). (IF: 5.61)
6. Huang L X, Hu J, Su Y Q, Qin Y X, Kong W D, Zhao L M, Ma Y, Xu X J, Lin M, Zheng J, Yan Q P. Genome-wide detection of predicted non-coding RNAs related to the adhesion process in Vibrio alginolyticus using high-throughput sequencing. Frontiers in Microbiology, 2016, 7: 619. (IF: 4.17)
7. Huang L X, Huang L, Yan Q P, Qin Y X, Ma Y, Lin M, Xu X J, Zheng J. The TCA pathway is an important player in the regulatory network governing Vibrio alginolyticus adhesion under adversity. Frontiers in Microbiology, 2016, 7: 40. (IF: 4.17)
8. Huang L X, Hu J, Su Y Q, Qin Y X, Kong W D, Ma Y, Xu X J, Lin M, Yan Q P. Identification and characterization of three Vibrio alginolyticus non-coding RNAs involved in adhesion, chemotaxis, and motility processes. Frontiers in Cellular & Infection Microbiology, 2015, 5: 56. (IF: 5.22)
9. Wang L, Huang L X, Su Y Q, Qin Y X, Kong W D, Ma Y, Xu X J, Lin M, Zheng J, Yan Q P. Involvement of the flagellar assembly pathway in Vibrio alginolyticus adhesion under environmental stresses. Frontiers in Cellular & Infection Microbiology, 2015, 5: 59. (Co-first authors). (IF: 5.22)
10. Kong W D, Huang L X, Su Y Q, Qin Y X, Ma Y, Xu X J, Lin M, Zheng J, Yan Q P*. Investigation of possible molecular mechanisms underlying the regulation of adhesion in Vibrio alginolyticus with comparative transcriptome analysis. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology. 2015, 107(5): 1197-206. (Co-first authors). (IF: 1.94)
11. Huang L X, Gao D X, Zhang Y Y, Wang C G, Zuo Z H*. Exposure to low dose benzo[a]pyrene during early life stages causes symptoms similar to cardiac hypertrophy in adult zebrafish. J Hazard Mater. 2014, 276: 377-82. (IF: 4.84)
12. Huang L X, Zuo Z H, Zhang Y Y, Wang C G*. Toxicogenomic analysis in the combined effect of tributyltin and benzo[a]pyrene on the development of zebrafish embryos. Aquat Toxicol. 2014, 158C: 157-164. (IF: 3.56)
13. Huang L X, Zuo Z H, Zhang Y Y, Wu M F, Lin J J, Wang C G*. Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity. Chemosphere. 2014, 108: 55-61. (IF: 3.70)
14. Huang L X, Wang C G, Zhang Y Y, Wu M F, Zuo Z H*. Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved. J Hazard Mater. 2013, 261: 172-80. (IF: 4.84)
15. Zhang Y Y, Huang L X, Zuo Z H, Chen Y X, Wang C G*. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Aquat Toxicol. 2013, 142-143: 26-32. (Co-first authors). (IF: 3.73)
16. Zhang Y Y, Huang L X, Wang C G, Gao D X, Zuo Z H*. Phenanthrene exposure produces cardiac defects during embryo development of zebrafish (Danio rerio) through activation of MMP-9. Chemosphere. 2013, 93(6): 1168-75. (Co-first authors). (IF: 3.70)
17. Huang L X, Wang C G, Zhang Y Y, Li J, Zhong Y F, Zhou Y L, Chen Y X, Zuo Z H*. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos. Chemosphere. 2012, 87(4): 369-75. (IF: 3.70)
五、联系方式
Email:lixinghuang@outlook.com
通讯地址:福建省厦门市集美区印斗路43号,集美大学mobile28-365365。邮编:361021。